The Desert Monitor is adapted to extreme heat and dryness. Burrows play a crucial role: in Israel, they measure on average 125 cm in length and 30 cm in depth[16]. In Algeria, burrows up to 3 m deep have been recorded[4]. In Morocco, neither the depth nor the complexity of burrows is documented, but the sandy and rocky substrates make similar shelters plausible. These burrows allow the animal to access a cooler and more humid microhabitat.
The species actively regulates its body temperature. In Egypt, its optimal body temperature is 35 to 38 °C, reached by basking in the morning and then held through to early afternoon. Activity stops below 20 °C, hibernation begins around 17 °C, and 44 to 47 °C is lethal[21][9]. In the field, active animals held body temperatures of 33.7 to 41.9 °C, emerged two to four hours after sunrise (earlier in summer), and showed a single activity peak in May and June[9]. The species is diurnal and has only exceptionally been recorded at dawn or after dark[14].
The Desert Monitor is active mainly in spring and autumn, while it likely remains confined to its burrows during the coldest periods of winter and the hottest periods of summer. In Algeria, two main activity periods have been described: from April to June, then in October[4]. In Mauritania, individuals have been observed until November[4]. In Morocco, we recorded monitor activity in the middle of summer, in August, using camera traps (pers. obs.). We also documented fresh tracks on many occasions during morning walks in multiple regions in August and September, indicating summer activity as well (pers. obs.). Monitors have also been observed by other herpetological groups in Morocco in the middle of summer (pers. comm.). It is therefore likely that monitors reduce their activity to the cooler hours of the day during the peak of summer, yet they still remain active.
Both local density and home-range size appear highly variable, tracking prey availability. Densities are higher in the more humid Saharan zones (about 6 individuals per km²) than in more arid areas (about 2 per km²)[19]. Home ranges are well defined and consistently larger in males than in females[18]. Their measured size differs markedly between regions, from about 0.075–0.228 km² in Sinai[10] and 0.32–0.98 km² in Israel[18] to 1–5 km² in Algeria[19]. In the Algerian Sahara, daily movements average 0.5–2.5 km on stony hamada and 0.1–1.2 km along wadis[20].